JOURNAL ARTICLE
REVIEW

How does the corpus callosum mediate interhemispheric transfer? A review

Lisette J van der Knaap, Ineke J M van der Ham
Behavioural Brain Research 2011 September 30, 223 (1): 211-21
21530590
The corpus callosum is the largest white matter structure in the human brain, connecting cortical regions of both hemispheres. Complete and partial callosotomies or callosal lesion studies have granted more insight into the function of the corpus callosum, namely the facilitation of communication between the cerebral hemispheres. How the corpus callosum mediates this information transfer is still a topic of debate. Some pose that the corpus callosum maintains independent processing between the two hemispheres, whereas others say that the corpus callosum shares information between hemispheres. These theories of inhibition and excitation are further explored by reviewing recent behavioural studies and morphological findings to gain more information about callosal function. Additional information regarding callosal function in relation to altered morphology and dysfunction in disorders is reviewed to add to the discussion of callosal involvement in interhemispheric transfer. Both the excitatory and inhibitory theories seem likely candidates to describe callosal function, however evidence also exists for both functions within the same corpus callosum. For future research it would be beneficial to investigate the functional role of the callosal sub regions to get a better understanding of function and use more appropriate experimental methods to determine functional connectivity when looking at interhemispheric transfer.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
21530590
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"