OPEN IN READ APP
JOURNAL ARTICLE

Serum uric acid as an independent and incremental prognostic marker in addition to N-terminal pro-B-type natriuretic peptide in patients with acute myocardial infarction

Myung Hwan Bae, Jang Hoon Lee, Sang Hyuk Lee, Sun Hee Park, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Jae Eun Jun, Shung Chull Chae
Circulation Journal: Official Journal of the Japanese Circulation Society 2011, 75 (6): 1440-7
21498911

BACKGROUND: There are limited data regarding the prognostic value of serum uric acid (UA) after acute myocardial infarction (AMI). We investigated whether UA predicts the prognosis independently and whether it has an incremental value to other factors, including N-terminal Pro-B-type natriuretic peptide (NT-ProBNP), in patients with AMI.

METHODS AND RESULTS: This study included 850 patients with AMI who were enrolled in the Korea AMI Registry from a single center. A major adverse cardiovascular event (MACE) was defined as a composite of death, recurrent myocardial infarction, and revascularization. During 6-month follow-up, MACE developed in 109 (12.8%). UA was higher in patients with MACE than in those without MACE (6.5 ± 2.4 mg/dl vs. 5.4 ± 1.8 mg/dl, P < 0.001). In the Cox-proportional hazard model, UA (hazard ratio [HR] 1.297, 95% confidence interval [CI] 1.075-1.565, P=0.007) was an independent predictor for 6-month MACE in addition to log NT-ProBNP (HR 2.362, 95%CI 1.007-5.539, P = 0.048), heart rate (HR 1.028, 95%CI 1.009-1.047, P = 0.004) and 3-vessel disease (HR 3.278, 95%CI 1.378 to 7.797, P = 0.007). UA had incremental prognostic value to conventional risk factors (chi-squar e= 8, P = 0.005), and to the combination of conventional factors and NT-ProBNP (chi-square = 10, P = 0.002).

CONCLUSIONS: UA is an independent predictor of short-term prognosis and has incremental value to NT-ProBNP in patients with AMI.

Comments

You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
21498911
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"