Frozen-thawed embryo transfer cycles: clinical outcomes of single and double blastocyst transfers

Inna Berin, Sarah T McLellan, Eric A Macklin, Thomas L Toth, Diane L Wright
Journal of Assisted Reproduction and Genetics 2011, 28 (7): 575-81

PURPOSE: To evaluate clinical outcomes of frozen-thawed embryo transfer cycles when one or two blastocysts are transferred.

METHODS: Retrospective chart review

RESULTS: Two hundred forty-three frozen blastocyst transfer (FBT) cycles were analyzed. Clinical pregnancy rate (50.4% vs. 34.7%), live birth rate (45.8% vs. 30.6%), and twin live birth rate (19.3% vs. 0) were significantly higher in the double versus single FBT group, respectively (p < 0.05). Prior fresh cycle success with same-cohort embryos did not predict outcome of FBT cycle. When the fresh cycle was unsuccessful, there still was a significant increase in twinning when two frozen-thawed blastocysts were transferred.

CONCLUSIONS: Transferring two blastocysts during an FBT cycle resulted in higher live birth and twin live birth rates. Single FBT provided acceptable pregnancy rates for couples seeking to avoid a multiple pregnancy or for those having a single blastocyst stored. Interestingly, the outcome of fresh cycle with same-cohort embryos did not influence the outcome of frozen-thawed cycle.

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