We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., EXTRAMURAL
Association of serum bicarbonate levels with gait speed and quadriceps strength in older adults.
American Journal of Kidney Diseases 2011 July
BACKGROUND: Metabolic acidosis is associated with skeletal muscle proteolysis, and alkali supplementation has shown improvements in lean body mass and urinary nitrogen wasting in several studies. However, the association of acidosis with functional outcomes has not been examined on a population-based level.
STUDY DESIGN: Cross-sectional study.
SETTING & PARTICIPANTS: 2,675 nationally representative adults 50 years or older in the National Health and Nutrition Examination Survey 1999-2002.
FACTOR: Serum bicarbonate level.
OUTCOMES: Low gait speed and low peak torque were defined as being in the lowest sex-specific quartile of gait speed and peak torque, respectively.
MEASUREMENTS: Serum bicarbonate was measured in all participants. Gait speed was determined from a 20-foot timed walk. Peak torque was calculated using peak isokinetic knee extensor force.
RESULTS: Serum bicarbonate level <23 mEq/L was present in 22.7% of the cohort. Compared with participants with bicarbonate levels ≥23 mEq/L, those with bicarbonate levels <23 mEq/L had higher body mass index and serum albumin levels; were more likely to have low socioeconomic status, a diagnosis of diabetes mellitus, or glomerular filtration rate <60 mL/min/1.73 m(2); and were less likely to use diuretics. Serum bicarbonate level <23 mEq/L compared with ≥23 mEq/L was associated with low gait speed (OR, 1.43; 95% CI, 1.04-1.95) and low peak torque (OR, 1.36; 95% CI, 1.07-1.74) after multivariable adjustment. The association with low peak torque was modified by race/ethnicity in women, but not men (ORs, 1.52 [95% CI, 1.08-2.13] for men, 2.33 [95% CI, 1.23-4.44] for nonwhite women, and 0.93 [95% CI, 0.47-1.82] for white women).
LIMITATIONS: Cross-sectional study using a single bicarbonate measurement.
CONCLUSIONS: Lower serum bicarbonate levels are associated with slower gait speed and decreased quadriceps strength in older adults. Further studies should examine the effect of alkali therapy on functional outcomes.
STUDY DESIGN: Cross-sectional study.
SETTING & PARTICIPANTS: 2,675 nationally representative adults 50 years or older in the National Health and Nutrition Examination Survey 1999-2002.
FACTOR: Serum bicarbonate level.
OUTCOMES: Low gait speed and low peak torque were defined as being in the lowest sex-specific quartile of gait speed and peak torque, respectively.
MEASUREMENTS: Serum bicarbonate was measured in all participants. Gait speed was determined from a 20-foot timed walk. Peak torque was calculated using peak isokinetic knee extensor force.
RESULTS: Serum bicarbonate level <23 mEq/L was present in 22.7% of the cohort. Compared with participants with bicarbonate levels ≥23 mEq/L, those with bicarbonate levels <23 mEq/L had higher body mass index and serum albumin levels; were more likely to have low socioeconomic status, a diagnosis of diabetes mellitus, or glomerular filtration rate <60 mL/min/1.73 m(2); and were less likely to use diuretics. Serum bicarbonate level <23 mEq/L compared with ≥23 mEq/L was associated with low gait speed (OR, 1.43; 95% CI, 1.04-1.95) and low peak torque (OR, 1.36; 95% CI, 1.07-1.74) after multivariable adjustment. The association with low peak torque was modified by race/ethnicity in women, but not men (ORs, 1.52 [95% CI, 1.08-2.13] for men, 2.33 [95% CI, 1.23-4.44] for nonwhite women, and 0.93 [95% CI, 0.47-1.82] for white women).
LIMITATIONS: Cross-sectional study using a single bicarbonate measurement.
CONCLUSIONS: Lower serum bicarbonate levels are associated with slower gait speed and decreased quadriceps strength in older adults. Further studies should examine the effect of alkali therapy on functional outcomes.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app