Effects of AST-120 on left ventricular mass in predialysis patients

Kentaro Nakai, Hideki Fujii, Keiji Kono, Shunsuke Goto, Masafumi Fukagawa, Shinichi Nishi
American Journal of Nephrology 2011, 33 (3): 218-23

BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in chronic kidney disease (CKD) patients. One of the proposed mechanisms assumes that accumulated uremic toxins play an important role in the progression of CVD in CKD. Recently, it has been reported that AST-120 may attenuate progression of CVD through absorption of uremic toxins. In this study, we examined the association between the use of AST-120 and cardiac abnormalities in CKD patients.

METHODS: This was a cross-sectional study of predialysis CKD patients hospitalized in our institution between April 2008 and October 2009. We divided 107 patients into two groups based on whether AST-120 had been administered for more than 6 months (AST-120 group: n = 43) or not (control group: n = 64). Echocardiography and laboratory tests were performed for all patients; we examined the relationship between clinical characteristics and cardiac abnormalities.

RESULTS: The number of patients with left ventricular (LV) concentric change was significantly smaller in the AST-120 group than in the control group. In multivariable analysis, the administration of AST-120, gender, and pulse pressure were significantly correlated with LV concentric change.

CONCLUSIONS: Our findings suggest that AST-120 prevents the development of LV concentric change in predialysis CKD patients.

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