Vasopressin analogues and V1a receptor agonists in septic shock

Marc O Maybauer, Dirk M Maybauer
Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.] 2011, 60 (5): 425-7
This article reviews the role of arginine-vasopressin and the vasopressin analogue terlipressin as potent alternative vasoconstrictors in the treatment of fluid and catecholamine-refractory septic shock. Terlipressin is the most selective, clinically available V1 receptor agonist, and may be more potent than arginine-vasopressin in restoring catecholamine refractory septic shock. Recent experimental and clinical studies on terlipressin, as well as the possible benefit of selective V1a receptor agonists, are discussed.

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