JOURNAL ARTICLE

Fast voice-coil scanning optical-resolution photoacoustic microscopy

Lidai Wang, Konstantin Maslov, Junjie Yao, Bin Rao, Lihong V Wang
Optics Letters 2011 January 15, 36 (2): 139-41
21263479
We developed a photoacoustic imaging system that has real-time imaging capability with optical resolution. The imaging system is capable of scanning at 20 Hz over a 9 mm range and up to 40 Hz over a 1 mm scanning range. A focused laser beam provides a lateral resolution of 3.4 μm as measured in an optically nonscattering medium. Flows of micrometer-sized carbon particles or whole blood in a silicone tube and individual red blood cells (RBCs) in mouse ear capillaries were also imaged in real time, demonstrating the capability to image highly dynamic processes in vivo at a micrometer-scale resolution.

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