JOURNAL ARTICLE

Large scale zebrafish-based in vivo small molecule screen

Jijun Hao, Charles H Williams, Morgan E Webb, Charles C Hong
Journal of Visualized Experiments: JoVE 2010, (46)
21248690
Given their small embryo size, rapid development, transparency, fecundity, and numerous molecular, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.

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