Molecular pathogenesis of cervical cancer

Okechukwu A Ibeanu
Cancer Biology & Therapy 2011 February 1, 11 (3): 295-306

INTRODUCTION: Cervical cancer is a sexually transmitted disease that results from infection with oncogenic types of human papillomavirus (HPV). Oncogenic HPV DNA is found in over 95% of invasive cervical cancers worldwide. Cervical cancer is a leading cause of cancer deaths in developing countries because of high HPV infection rates and lack of comprehensive cervical Pap smear testing of susceptible women. Vaccination against HPV prevents the acquisition of cervical dysplastic lesions among eligible women who have not already acquired the vaccine-specific HPV types.

METHODS: Literature review of the epidemiology, infection cycle, viral gene function and current vaccines related to the oncogenic types of the human papillomavirus (HPV).

CONCLUSION: Enhanced understanding of HPV and population-based measures offer the best hope of limiting worldwide mortality due to cervical cancer. The development of therapeutic cervical cancer vaccines and/or virus-targeted drug therapies would be a giant step forward.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.