OPEN IN READ APP
JOURNAL ARTICLE

Control of urinary risk factors of stone formation by Salvadora persica in experimental hyperoxaluria

K Geetha, R Manavalan, D Venkappayya
Methods and Findings in Experimental and Clinical Pharmacology 2010, 32 (9): 623-9
21225013
Urolithiasis, the process of formation of stones in the kidneys and urinary tract, is the major clinical manifestation of hyperoxaluria. Ethylene glycol feeding resulted in hyperoxaluria with increased renal excretion of oxalate, sodium, calcium and phosphate and a decrease in the excretion of magnesium. Supplementation with an aqueous and alcoholic extract of the leaves of Salvadora persica significantly reduced elevated urinary oxalate levels, indicating a regenerative action on endogenous oxalate synthesis. The deposition of stone-forming constituents in the kidneys of calculogenic rats was also significantly lowered by curative and preventive treatments with the aqueous and alcoholic extracts of Salvadora persica. The high serum creatinine level observed in ethylene glycol-treated rats was also reduced following treatment with the extracts. Histopathological findings showed signs of improvement after treatment with the extracts. These observations led to the conclusion that the aqueous and alcoholic extracts of the leaves of Salvadora persica are endowed with antiurolithiatic properties.

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
21225013
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"