[Efficacy and securyty of therapeutic hypothermia for hypoxic ischemic encephalopathy: a meta-analysis]

A Rizzotti, José Bas, Eduardo Cuestas
Revista de la Facultad de Ciencias Médicas 2010, 67 (1): 15-23

BACKGROUND: Animal and human experimental models suggest that therapeutic hypothermia could reduce neurological disabilities in asphyxiated newborn without adverse events. The objective of this study was review the effectiveness and safety of hypothermia as treatment for hypoxic ischemic encephalophaty.

METHODS: MEDLINE, COCHRANE LIBRARY, Academic Google and LILACS databases were searched. Randomized controlled trials with main outcomes of death, neurodevelopmental disability and adverse events were eligible for inclusion in the meta-analysis.

RESULTS: Tree studies were included with 751 patients. Combined results of death reduction was not significant (RR 0.83 CI95% 0.67 to 1.04). Severe to moderate neurodevelopmental disability (RR 0.70 CI95% 0.55 to 0.89) and cerebral palsy (RR 0.66 CI95% 0.50 to 0.89) were reduced significantly in newborns receiving hypothermia compared with controls. Cardiac arrhythmias (RR 3.51 CI95% 1.29 to 9.54) and coagulation disorders (RR 1,23 CI95% 1.03 a 1.48) were more common adverse events with hypothermia.

CONCLUSIONS: Hypothermia is effective in reducing neurological disability and cerebral palsy. Cardiac arrhythmias and coagulation disorders were more common with hypothermia, however they were clinically benign.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"