Design of an in-dwelling cannula for convection-enhanced delivery

Kathryn H Rosenbluth, Matthias Luz, Erich Mohr, Stephan Mittermeyer, John Bringas, Krystof S Bankiewicz
Journal of Neuroscience Methods 2011 March 15, 196 (1): 118-23
Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion.

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