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JOURNAL ARTICLE

Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma

Cristina Motlló, Javier Grau, Jordi Juncà, Neus Ruiz, José-Luis Mate, Elisa Orna, José-Tomás Navarro, Susana Vives, Juan-Manuel Sancho, Daniel Esteban, Isabel Granada, Evarist Feliu, Josep-Maria Ribera, Fuensanta Millá
Cancer Genetics and Cytogenetics 2010, 203 (2): 328-32
21156254
Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. This lymphoma usually shows MYC rearrangements with non-IGH genes in the setting of a complex karyotype possibly involving BCL2 and, less frequently, BCL6 rearrangements. According to the presence of two or three rearrangements, these lymphomas are called double-hit lymphomas or triple-hit lymphomas (THL), respectively. Here we report two cases of THL with MYC, BCL2, and BCL6 rearrangements and t(3;8)(q27;q24) diagnosed in one center in the last two years.

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