JOURNAL ARTICLE
REVIEW

The role of HLA-G in immunity and hematopoiesis

Edgardo D Carosella, Silvia Gregori, Nathalie Rouas-Freiss, Joel LeMaoult, Catherine Menier, Benoit Favier
Cellular and Molecular Life Sciences: CMLS 2011, 68 (3): 353-68
21116680
The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto-maternal tolerance. Since this discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response. In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors, (3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis and angiogenesis.

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