JOURNAL ARTICLE

Ameloblastic carcinoma, secondary type: a case report

Kazunari Karakida, Takayuki Aoki, Haruo Sakamoto, Miho Takahashi, Tadashi Akamatsu, Go Ogura, Yasutomo Sekido, Yoshihide Ota
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 2010, 110 (6): e33-7
21112523
Malignant variants of ameloblastoma include metastasizing ameloblastoma, which microscopically appears benign but has metastasized and ameloblastic carcinoma that exhibits malignant histopathologic features. Ameloblastic carcinoma is classified into 2 types: a primary odontogenic malignancy and a secondary type resulting from malignant transformation of ameloblastoma. Most secondary ameloblastic carcinomas result from malignant transformation of a primary lesion after repeated postsurgical recurrences. Therefore it is rare to find an untreated secondary type presenting with histologic features of malignant transformation from an earlier benign lesion. We experienced a rare case of ameloblastic carcinoma, secondary type which might arise in an untreated ameloblastoma. The mechanism by which a preexisting benign ameloblastoma goes through a malignant transformation is also described.

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