Periodontal disease is related to local and systemic mediators of inflammation.

Ananda P Dasanayake

Journal of Evidence-based Dental Practice 2010 December

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis. Fitzsimmons TR, Sanders AE, Bartold PM, Slade GD. J Clin Periodontol 2010;37(1):30-6.

REVIEWER: Ananda P. Dasanayake, BDS, MPH, PhD, FACE.

PURPOSE/QUESTION: The authors attempted to study the independent and combined effects of local (IL-1β) and systemic (CRP) inflammatory biomarkers in gingival crevicular fluid (GCF) on the risk of periodontitis.

SOURCE OF FUNDING: Government: National Health and Medical Research Council (NHMRC) of Australia and NHMRC Sidney Sax Public Health Fellowship.

TYPE OF STUDY/DESIGN: Case-control study.

LEVEL OF EVIDENCE: Level 2: Limited-quality, patient-oriented evidence.

STRENGTH OF RECOMMENDATION GRADE: Not applicable.

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