Letter to the editor: Panaxadiol's anticancer activity is enhanced by epicatechin

Miguel Rodriguez, Guang-Jian Du, Chong-Zhi Wang, Chun-Su Yuan
American Journal of Chinese Medicine 2010, 38 (6): 1233-5
We previously reported the antiproliferative effect of panaxadiol (PD), an active compound in steamed ginseng, on human HCT-116 colorectal cancer cells, and that antioxidants might play a role in this effect. In this study, we observed that PD's antiproliferative effect was significantly enhanced by epicatechin (EC), a strong natural antioxidant in grape seed. Evidence for the synergistic antiproliferative effect was supported by the remarkable increase in the number of apoptotic cells.

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