Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study

Bjørn Olav Asvold, Trine Bjøro, Lars J Vatten
European Journal of Endocrinology 2011, 164 (1): 101-5

OBJECTIVE: Low thyroid function may be associated with reduced glomerular filtration rate (GFR). We therefore studied the association of thyroid function with estimated GFR (eGFR) in a population-based study.

DESIGN: A cross-sectional, population-based study of 29 480 individuals above 40 years of age, without previously known thyroid disease.

METHODS: We calculated geometric mean eGFR and odds ratio (OR) of chronic kidney disease (CKD; eGFR <60 ml/min per 1.73 m(2)) according to categories of thyroid function, using people with TSH in the lower third of the reference range (0.50-1.4 mU/l) as the comparison group.

RESULTS: TSH within the reference range (0.50-3.5 mU/l) was negatively associated with eGFR (P for trend <0.001). Compared with people with TSH in the lower third of the reference range (83.0 ml/min per 1.73 m(2)), eGFR was lower in people with TSH in the middle (81.6 ml/min per 1.73 m(2)) and highest third (80.3 ml/min per 1.73 m(2)) of the reference range, and in people with subclinical (79.3 ml/min per 1.73 m(2), P<0.001) or overt hypothyroidism (76.5 ml/min per 1.73 m(2), P<0.001). The prevalence of CKD was higher in people with TSH in the middle (OR 1.20, 95% confidence interval (CI) 1.07-1.35) or highest third (OR 1.31, 95% CI 1.13-1.52) of the reference range, compared with people in the reference group. Also, CKD was more common in people with subclinical (OR 1.63, 95% CI 1.38-1.93) or overt (OR 1.98, 95% CI 1.22-3.20) hypothyroidism.

CONCLUSIONS: These findings suggest that low thyroid function, also within the clinically normal range, is associated with reduced GFR.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"