Early blood exchange transfusion in malignant pertussis: a case report

Manuel Martinez, Isabelle Rochat, Regula Corbelli, Pierre Tissières, Peter C Rimensberger, Constance Barazzone-Argiroffo
Pediatric Critical Care Medicine 2011, 12 (2): e107-9

OBJECTIVE: To report early blood exchange transfusion in malignant pertussis and a favorable clinical outcome.

SETTING: A pediatric intensive care unit in a tertiary hospital in Geneva, Switzerland.

DESIGN: A descriptive case report.

PATIENT: An 8-wk-old girl was diagnosed with malignant pertussis (extreme leukocytosis, seizures, pneumonia, and secondary severe hypoxic respiratory failure associated with pulmonary hypertension). After administration of a one-volume blood exchange transfusion, a rapid decrease in white blood cell count (from 119,000/mm(3) to 36,500/mm(3)) was observed and followed by clinical improvement and favorable outcome despite the initial presence of all described risk factors associated with a high mortality.

CONCLUSION: The use of exchange blood transfusion early in the course of the disease might help to prevent a fatal outcome of malignant pertussis.

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