Use of bovine hydroxyapatite with or without biomembrane in sinus lift in rabbits: histopathologic analysis and immune expression of core binding factor 1 and vascular endothelium growth factor

Leandro Soeiro De Souza Nunes, Renato Victor De Oliveira, Leandro Andrade Holgado, Hugo Nary Filho, Daniel Araki Ribeiro, Mariza Akemi Matsumoto
Journal of Oral and Maxillofacial Surgery 2011, 69 (4): 1064-9

PURPOSE: Considering the clinical discussion on the necessity of using a barrier membrane in the osteotomy area of sinus lift procedures to prevent fibrous tissue formation in this area and as a physical limit, the aim of this study was to analyze and compare the use of bovine hydroxyapatite (HA) with and without a biologic membrane by histopathologic analysis and immune expression of core binding factor 1 and vascular endothelium growth factor in the sinus lift in rabbits.

MATERIALS AND METHODS: Sixteen male rabbits underwent bilateral sinus lift procedures and were divided into 2 groups according to the sinus filling material: group 1 received bovine HA (Bio-Oss; Geistlich Pharma AG, Wohlhusen, Switzerland) and group 2 received bovine HA and a nonporous polytetrafluorethylene membrane. All groups were sacrificed after 7, 14, 30, and 60 days for microscopic, histomorphometric, and immunohistochemical analyses.

RESULTS: Microscopic analysis showed a similar bone repair pattern between the tested groups. New bone formation, soft tissue, and the remaining material were analyzed by histomorphometric analysis. No statistically significant differences (P > .05) were detected between groups for all periods analyzed. In addition, no remarkable differences were noticed in core binding factor 1 or vascular endothelium growth factor immune expression.

CONCLUSION: Taken together, these results show that using a biologic membrane does not improve bone repair induced by bovine HA, as shown by histopathologic and immunohistochemical analyses.

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