COMPARATIVE STUDY
JOURNAL ARTICLE

Uric Acid as prognostic marker in advanced nonischemic dilated cardiomyopathy: comparison with N-terminal pro B-type natriuretic peptide level

Hyungseop Kim, Hong-Won Shin, Jihyun Son, Hyuck-Jun Yoon, Hyoung-Seob Park, Yun-Kyeong Cho, Choon-Duk Han, Chang-Wook Nam, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim
Congestive Heart Failure 2010, 16 (4): 153-8
20662867
Although uric acid (UA) level has been associated with an increased risk of cardiovascular events, it is unclear whether UA can provide greater prognostic information than N-terminal pro B-type natriuretic peptide (NT-proBNP) in advanced heart failure with nonischemic dilated cardiomyopathy (DCM). UA and NT-proBNP values were obtained from a total of 122 DCM patients. Development of clinical events during follow-up was defined as the composite of cardiac death and readmission for heart failure. During follow-up, there were 18 cardiac events. UA and NT-proBNP values were significantly higher in patients with events. The receiver operating characteristics curve showed the area under the curve for UA was greater than that for NT-proBNP. On multivariate analysis, UA remained the only independent predictor of prognosis. UA concentrations > or =8.7 mg/dL rather than NT-proBNP > or =3800 pg/mL were associated with significantly decreased event-free survival. The authors' findings demonstrated that UA value could be an informative predictor in nonischemic DCM.

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