HLA-G*0105N allele is associated with augmented risk for HIV infection in white female patients

Ludovica Segat, Eulalia Catamo, Annalisa Fabris, Marcello Morgutti, Pierlanfranco D'Agaro, Cesare Campello, Sergio Crovella
AIDS 2010 July 31, 24 (12): 1961-4
We analyzed HLA-G 3777G > C, HLA-G 14 bp deletion/insertion and HLA-G*0105N polymorphisms in HIV-positive white adult participants, infected through horizontal heterosexual transmission, and unexposed uninfected individuals, all from north eastern Italy. We report a new association between the HLA-G*0105N allele and HIV infection in adult white female participants, being HLA-G*0105N null allele correlated with an augmented risk (odds ratio = 4.35, 95% confidence interval = 1.38-18.07, P = 0.005) for HIV infection.

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