Understanding latent tuberculosis: a moving target

Philana Ling Lin, Joanne L Flynn
Journal of Immunology: Official Journal of the American Association of Immunologists 2010 July 1, 185 (1): 15-22
Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection. Latently infected persons, of which there are estimated to be approximately 2 billion in the world, represent an enormous reservoir of potential reactivation TB, which can spread to other people. The immunology of TB is complex and multifaceted. Identifying the immune mechanisms that lead to control of initial infection and prevent reactivation of latent infection is crucial to combating this disease.

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