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Takayasu arteritis in children and adolescents

Juergen Brunner, Brian M Feldman, Pascal N Tyrrell, Jasmin B Kuemmerle-Deschner, Lothar B Zimmerhackl, Ingmar Gassner, Susanne M Benseler
Rheumatology 2010, 49 (10): 1806-14
Takayasu arteritis is a devastating vasculitis of the aorta and its major branches. The clinical manifestations in paediatric patients are less specific than in adults: in children the disease presents with fever, arthralgias and hypertension. Intramural inflammation results in narrowing of the blood vessel lumen and therefore hypoperfusion of the parenchyma. Conventional angiography is the gold standard diagnostic procedure. Corticosteroids, cyclophosphamide, MTX and biological therapies such as TNF-α blocking agents are treatment options.

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