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Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis.

Xiao Luo, Jian-Xin Pu, Wei-Lie Xiao, Yong Zhao, Xue-Mei Gao, Xiao-Nian Li, Hai-Bo Zhang, Yuan-Yuan Wang, Yan Li, Han-Dong Sun
Journal of Natural Products 2010 June 26
Ten new ent-kaurane diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human cancer cell lines, and some exhibited quite potent inhibitory activities.

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