Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis

Igor Koturbash, Franz J Zemp, Igor Pogribny, Olga Kovalchuk
Mutation Research 2011 June 17, 722 (2): 94-105
Small non-coding RNAs-microRNAs, are potent negative regulators of gene expression. MicroRNAs are involved in multiple biological processes, metabolic regulation, including cell proliferation, differentiation, and programmed cell death. Since the dysregulation of these processes is a hallmark of cancer, microRNAs can be viewed as major contributors to the pathogenesis of cancer, including initiation and progression of cancer. This review focuses on microRNA biogenesis and function, and their role in cancer, metastasis, drug resistance, and tumorigenesis.

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