Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta

Nina Eriksen, Anette Kirstine Stark, Bente Pakkenberg
Journal of Neural Transmission. Supplementum 2009, (73): 203-13
During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.

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