[Normal connective tissue in penis and its changes in patients with erectile dysfunction and Peyronie's disease]

A I Neĭmark, V V Klimachev, V Ia Gerval'd, I P Bobrov, A M Avdalian, N I Muzalevskaia, I V Gerval'd, R T Aliev, M A Kazymov
Morfologi︠a︡ 2009, 136 (6): 75-8
The aim of this study was to examine the connective tissue of penis in normal individuals and in patients with erectile dysfunction (ED) and Peyronie's disease (PD) using computer methods of image analysis. Penis tissues were obtained from 20 males aged 20-40 years who died in accidents, penis biopsies were taken from 23 patients with ED and 9 patients with PD (average age: 51 +/- 11.5 years). In both groups of patients, the volumetric fraction of collagen fibers in the tunica albuginea and corpora cavernosa was increased, while that one of elastic fibers was decreased. At the same time, the changes of elastic fibers were noted: the fibers become thinner and formed "rods". The reduction of the amplitude and the wavelength in the collagen fibers of the tunica albuginea in patients with ED and the presence of fibrous plaques in corpora cavernosa in in patients with PD were registered. The methods of computer image analysis may improve the morphologic diagnosis of ED and PD.

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