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Research Support, Non-U.S. Gov't
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A new geldanamycin analogue from Streptomyces hygroscopicus.

Hao Zhang, Guang-Zhi Sun, Xiang Li, Hong-Yu Pan, Yan-Sheng Zhang
Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry 2010 March
A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).

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