Comparison of topical Xylocaine with placebo as a local anesthetic in colposcopic biopsies

M Prefontaine, M Fung-Kee-Fung, D Moher
Canadian Journal of Surgery. Journal Canadien de Chirurgie 1991, 34 (2): 163-5
Colposcopically directed biopsies cause discomfort for the patient. Topical lidocaine (Xylocaine) had routinely been applied to the cervix before biopsies performed at the colposcopy clinic of the Ottawa General Hospital. A prospective, single-blind trial was performed to compare the effect of topical Xylocaine with that of a placebo. Patients in both groups experienced discomfort; the median pain score in both groups was equal, and statistical analysis of the results by the Mann-Whitney test showed no difference between the two treatment groups.

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