Persistent symptoms in mild to moderate traumatic brain injury associated with executive dysfunction

Kaisa M Hartikainen, Minna Waljas, Tuulia Isoviita, Prasun Dastidar, Suvi Liimatainen, Anne-Kristin Solbakk, Keith H Ogawa, Seppo Soimakallio, Aarne Ylinen, Juha Ohman
Journal of Clinical and Experimental Neuropsychology 2010, 32 (7): 767-74
In order to improve detection of subtle cognitive dysfunction and to shed light on the etiology of persistent symptoms after mild-to-moderate traumatic brain injury (TBI), we employed an experimental executive reaction time (RT) test, standardized neuropsychological tests, and diffusion tensor imaging (DTI). The Executive RT-Test, an Executive Composite Score from standardized neuropsychological tests, and DTI-indices in the midbrain differentiated between patients with persistent symptoms from those fully recovered after mild-to-moderate TBI. We suggest that persistent symptoms in mild-to-moderate TBI may reflect disrupted fronto-striatal network involved in executive functioning, and the Executive RT-Test provides an objective and novel method to detect it.

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