Histopathological and clinical-progressive profile of skin carcinomas: study on 1688 cases

V Pătraşcu, Loredana Elena Stoica, Claudia Valentina Georgescu, Emilia Pătru
Romanian Journal of Morphology and Embryology 2010, 51 (1): 171-80
Skin carcinomas represent 90-95% of skin cancers. With the objective of identifying the histopathological and clinical-progressive profile of skin carcinomas, we undertook a retrospective study over a period of seven years, which included a total of 1688 patients with carcinoma of the skin, hospitalized and treated in Craiova Dermatology Clinic between January 1999 and December 2006. Patient data such as identification data, environment, profession, phototype, location of cancer, history of the disease, clinical diagnosis, histopathological diagnosis and response to treatment were included in clinical charts. Basal cell carcinoma (BCC) was diagnosed in a total of 1162 patients, representing 68.84% of cases taken to the study. The most common clinical forms were: pearly BCC (37.95%), nodular BCC (29%), and superficial BCC (22.03%). Regarding the histological type, the most frequent forms were: BCC polymorphic (29.95%), BCC solid (24.96%), and keratinized BCC (19.97%). Epidermoid carcinoma (EC) was encountered in a total of 482 patients, representing 28.55% of all cases. The most frequent forms were: vegetated ulcerated EC (34.03%), nodular EC (31.33%) and keratosic EC (24.27%). Regarding the degree of differentiation, the situation was as follows: well-differentiated EC (64.94%), medium differentiated (29.88%), poorly differentiated (5.18%). Metatypical carcinoma (MC) was found in 44 patients (2.61%). This type of cancer did not presented clinical particular signs, the diagnosis was strictly pathological.

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