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[Development of hair follicle stem cells related signal transduction in proliferation and differentiation].

Yongan Xu, Xiaobing Fu
Chinese Journal of Reparative and Reconstructive Surgery 2010 Februrary
OBJECTIVE: To introduce the basic research and clinical potential of the hair follicle stem cells related signal transduction in proliferation and differentiation.

METHODS: The recent original articles about the hair follicle stem cells were extensively reviewed.

RESULTS: Many different signal pathways had been involved in the skin development and self-newals.The hair follicle stem cells could play an important role in the skin self-renewal and regeneration which were modulated by several different signal pathways, which included bone morphogenetic protein/transforming growth factor beta, Wnt, Notch and ectodysplasin A genes.

CONCLUSION: The hair follicle stem cells may be a future approach to repair cutaneous wounds as a cell therapy.

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