Swimming into the future of drug discovery: in vivo chemical screens in zebrafish

Teresa V Bowman, Leonard I Zon
ACS Chemical Biology 2010 February 19, 5 (2): 159-61
In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.

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