Light chain deposition disease as a rare cause of restrictive cardiomyopathy

Pieter Koopman, Jo Van Dorpe, Bart Maes, Karl Dujardin
Acta Cardiologica 2009, 64 (6): 821-4
We report an unusual case of a 47-year-old Caucasian woman who presented with severe dyspnoea as a manifestation of restrictive cardiomyopathy, found to be due to myocardial deposition of kappa light chains. Non-routine specific immunofluorescence stainings of endomyocardial biopsy specimens were key for the diagnosis of myocardial light chain deposition disease. We discuss non-amyloidotic cardiac immunoglobulin deposition disease in contrast to cardiac amyloidosis.

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