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Prognostic factors in desmoid-type fibromatosis: a clinicopathological and immunohistochemical analysis of 46 cases.
Pathology 2010 Februrary
AIMS: To determine risk factors for recurrence of desmoid-type fibromatosis (aggressive fibromatosis).
METHODS: Forty-six cases of desmoid-type fibromatosis in Taiwanese patients were analysed for an association between tumour recurrence and clinical features, pathology, and the presence of p53 protein and beta-catenin on immunohistochemical staining.
RESULTS: Six (13%) of 46 patients developed recurrence after surgical resection. The only factor significantly associated with tumour recurrence was positive surgical margin (p = 0.035).
CONCLUSIONS: A positive surgical margin is a risk factor for recurrence of desmoid-type fibromatosis.
METHODS: Forty-six cases of desmoid-type fibromatosis in Taiwanese patients were analysed for an association between tumour recurrence and clinical features, pathology, and the presence of p53 protein and beta-catenin on immunohistochemical staining.
RESULTS: Six (13%) of 46 patients developed recurrence after surgical resection. The only factor significantly associated with tumour recurrence was positive surgical margin (p = 0.035).
CONCLUSIONS: A positive surgical margin is a risk factor for recurrence of desmoid-type fibromatosis.
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