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COMPARATIVE STUDY
JOURNAL ARTICLE
Optimal designs for two-arm, phase II clinical trial design with multiple constraints.
Journal of Biopharmaceutical Statistics 2010 January
Multi-stage Phase II trials are often employed in practice but may not be the best approach when the endpoint of interest is not obtained soon after enrollment and/or when a control arm is desired. We present a new design in which sample size determination includes a control arm and allows for the estimation of response for each treatment as well as estimation of the difference in the response rates. We evaluate this design under varying allocation schemes to treatment arms and response rates for each treatment.
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