Myelodysplastic syndromes: a practical approach to diagnosis and treatment

Afsaneh Barzi, Mikkael A Sekeres
Cleveland Clinic Journal of Medicine 2010, 77 (1): 37-44
The myelodysplastic syndromes (MDS) are clonal bone marrow disorders that lead to underproduction of normal blood cells. The consequent cytopenias result in infections and bleeding complications. MDS transform to acute myeloid leukemia in one-third of patients. The number of diagnoses has exploded in the past decade as a result of increased recognition and understanding of the disease and the aging of the population. New therapies can extend life. MDS are now considered the most common form of leukemia, and in some cases deserve immediate intervention. This review describes common presentations of MDS, optimal diagnostic approaches, and therapies for lower-and higher-risk disease.

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Lina Bie

Super paper!


junaid hussain

Great article


bishal shrestha

Simple and informative


Hisham Yousef

Most common form of leukemia.
Perfect description!


Roberto Cruz

Interesting paper, it would be amazing to put the main indications of bone marrow transplant


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