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Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China.

Yong Zhang, Dongyan Wang, Dongmei Yan, Shuangli Zhu, Jianfeng Liu, Haiyan Wang, Shengcang Zhao, Deshan Yu, Lijuan Nan, Junjing An, Li Chen, Hongqiu An, Aiqiang Xu, Wenbo Xu
Journal of Clinical Microbiology 2010 Februrary
The molecular epidemiology of CVA16 in China between 1999 and 2008 reflects a pattern of endemic cocirculation of clusters B1a and B1b within subgenotype B1 viruses. The annual evolution rate of CVA16 was estimated as approximately 0.91 x 10(-2) substitutions per synonymous nucleotide/year and is slightly lower than that of HEV71.

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