SupportLoginSign Up
Featured FeedJournalsCollectionsKeywords
Add like
Add dislike
Add to saved papers

Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.

Eric J Gilbert, Guowei Zhou, Michael K C Wong, Ling Tong, Bandarpalle B Shankar, Chunli Huang, Joseph Kelly, Brian J Lavey, Stuart W McCombie, Lei Chen, Razia Rizvi, Youhao Dong, Youheng Shu, Joseph A Kozlowski, Neng-Yang Shih, R William Hipkin, Waldemar Gonsiorek, Asra Malikzay, Charles A Lunn, Len Favreau, Daniel J Lundell
Bioorganic & Medicinal Chemistry Letters 2010 January 16
The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C9 inhibition is described.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.
Show additional links to paperHide additional links to paper
PubMed

Add to Saved Papers

Get 1-tap access

Related Resources

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

Do Not Sell My Personal InformationManage Cookie Preferences

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app