Lack of association between the paraoxonase 1 Q/R192 single nucleotide polymorphism and stroke in a Chinese cohort.

BACKGROUND: Serum paraoxonase (PON1) is an HDL-associated esterase that hydrolyzes products of lipid peroxidation and prevents the oxidation of LDL. Paraoxonase 1 (PON1) was implicated in susceptibility to stroke in previous studies. We investigated the correlation between the paraoxonase Gln-Arg 192 polymorphism (PON1Q/R192) and stroke including cerebral hemorrhage and cerebral infarction.

METHOD: The association between the paraoxonase Gln-Arg 192 polymorphism (PON1Q/R192) and stroke was investigated in 1019 subjects, which involved 305 cases with cerebral hemorrhage, 375 cases with cerebral infarction and 339 healthy controls.

RESULTS: The PON1Q/R192 genotype distribution in the cerebral hemorrhage group was QQ13.1%, QR48.2% and RR38.7% and in the cerebral infarction group was QQ13.6%, QR44.0% and RR42.4% respectively. There was no significant difference in PON1Q/R192 allele and genotype distribution between the patient group and the control group (P > 0.05). The PON1 polymorphism was not associated with cerebral hemorrhage or infarction.

CONCLUSION: Our study suggests that serum paraoxonase (PON1) is not associated with cerebral hemorrhage or infarction, although it is a lipolactonase which is associated with HDL-apolipoprotein A-I (HDL-apoA-I) and plays a role in the prevention of atherosclerosis.