JOURNAL ARTICLE
REVIEW

Attributable mortality of Stenotrophomonas maltophilia infections: a systematic review of the literature

Matthew E Falagas, Antonia C Kastoris, Evridiki K Vouloumanou, Petros I Rafailidis, Anastasios M Kapaskelis, George Dimopoulos
Future Microbiology 2009, 4 (9): 1103-9
19895214

AIM: Although Stenotrophomonas maltophilia is commonly isolated from clinical specimens, mainly of immunocompromised patients, mortality directly attributable to this organism is controversial. We searched PubMed, Scopus and Cochrane and assessed the available literature regarding mortality attributable to infection with S. maltophilia.

METHOD: Crude mortality and mortality of case patients receiving appropriate or inappropriate initial antibiotic treatment were evaluated. A total of 15 articles (six matched case-control, seven case-control and two controlled cohort studies) were identified; 13 studies (the six matched case-control and the seven case-control studies) were included in the analysis.

RESULTS: In seven studies, mortality of cases differed significantly from that of controls. Mortality was significantly higher in cases than controls in six of these studies; it was lower in cases than controls in the one study where controls had Pseudomonas aeruginosa bacteremia. In six studies, mortality of cases did not differ significantly compared with the respective controls. In three of four studies providing relevant data, mortality of cases treated with inappropriate initial antibiotic treatment was significantly higher compared with cases treated with appropriate initial antibiotic treatment.

CONCLUSION: A considerable mortality rate (up to 37.5%) can be attributed to S. maltophilia infection. Thus, clinicians should not underestimate the clinical significance of S. maltophilia infections.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
19895214
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.