Retrospective comparison of mobilization methods for autologous stem cell transplantation in multiple myeloma

Hideki Nakasone, Yoshinobu Kanda, Tomoki Ueda, Kenji Matsumoto, Naomi Shimizu, Jiro Minami, Rika Sakai, Maki Hagihara, Akira Yokota, Kumi Oshima, Yuiko Tsukada, Takayoshi Tachibana, Chiaki Nakaseko, Shin Fujisawa, Shingo Yano, Hiroyuki Fujita, Satoshi Takahashi, Heiwa Kanamori, Shinichiro Okamoto et al.
American Journal of Hematology 2009, 84 (12): 809-14
The combination of cyclophosphamide and granulocyte-colony stimulating factor (G-CSF) has widely been used to mobilize hematopoietic stem cells (HSCs) for autologous stem cell transplantation (ASCT) for multiple myeloma (MM). Recently, however, alternative approaches such as G-CSF alone or etoposide followed by G-CSF have been investigated. We, therefore, retrospectively analyzed the effects of these mobilization methods on collection yield and disease outcome in ASCT for MM. We reviewed 146 MM patients from whom we intended to collect stem cells. For mobilization, 67, 58, and 21 patients received cyclophosphamide and G-CSF, etoposide and G-CSF, and G-CSF alone (including nonmyelosuppressive chemotherapy followed by G-CSF), respectively. Among them, 136 achieved the target number of HSCs (at least 2 x 10(6)/kg). Lower creatinine and higher albumin levels at diagnosis were significantly associated with successful yield. A lower number of infused HSCs, use of the etoposide for mobilization and high ISS were associated with delayed hematopoietic recovery. The mobilization methods did not significantly affect either the successful collection of more than 2 x 10(6) CD34-positive cells/kg or PFS after ASCT. G-CSF alone was sufficient for stem cell mobilization for a single ASCT. The optimal approach to collect HSCs in MM remains to be elucidated.

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