JOURNAL ARTICLE
MULTICENTER STUDY

Multicenter study of prevalence of nontuberculous mycobacteria in patients with cystic fibrosis in france

Anne-Laure Roux, Emilie Catherinot, Fabienne Ripoll, Nathalie Soismier, Edouard Macheras, Sophie Ravilly, Gil Bellis, Marie-Anne Vibet, Evelyne Le Roux, Lydie Lemonnier, Cristina Gutierrez, Véronique Vincent, Brigitte Fauroux, Martin Rottman, Didier Guillemot, Jean-Louis Gaillard
Journal of Clinical Microbiology 2009, 47 (12): 4124-8
19846643
We performed a multicenter prevalence study of nontuberculous mycobacteria (NTM) involving 1,582 patients (mean age, 18.9 years; male/female ratio, 1.06) with cystic fibrosis in France. The overall NTM prevalence (percentage of patients with at least one positive culture) was 6.6% (104/1,582 patients), with prevalences ranging from 3.7% (in the east of France) to 9.6% (in the greater Paris area). Mycobacterium abscessus complex (MABSC; 50 patients) and Mycobacterium avium complex (MAC; 23 patients) species were the most common NTM, and the only ones associated with fulfillment of the American Thoracic Society bacteriological criteria for NTM lung disease. The "new" species, Mycobacterium bolletii and Mycobacterium massiliense, accounted for 40% of MABSC isolates. MABSC species were isolated at all ages, with a prevalence peak between 11 and 15 years of age (5.8%), while MAC species reached their highest prevalence value among patients over 25 years of age (2.2%).

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