Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies

Li Li, Konstantin Maslov, Geng Ku, Lihong V Wang
Optics Express 2009 September 14, 17 (19): 16450-5
Photoacoustic microscopy is predominantly sensitive to optical absorption, while optical coherence tomography relies on optical backscattering. Integrating their complementary contrasts can provide comprehensive information about biological tissue. We have developed a dual-modality microscope that combines the two for studying microcirculation. Three-dimensional imaging of microvasculature and its local environment has been demonstrated at micrometer-order resolution using endogenous contrast in vivo.

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