JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
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Treatment of recurrent aphthous stomatitis with clofazimine.

OBJECTIVE: The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis.

STUDY DESIGN: In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms.

RESULTS: A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with
CONCLUSION: Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.

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