Treatment of recurrent aphthous stomatitis with clofazimine.

Marilda Aparecida Milanez Morgado de Abreu, Cleonice Hitomi Watashi Hirata, Dalva Regina Neto Pimentel, Luc Louis Maurice Weckx

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 2009 November

OBJECTIVE: The aim was to investigate the safety and efficacy of clofazimine for the treatment of recurrent aphthous stomatitis.

STUDY DESIGN: In this randomized controlled partially blind study, 23 patients received clofazimine 100 mg daily for 30 days and then 100 mg every other day. Twenty-three patients received colchicine 0.5 mg 3 times daily. Twenty patients received 1 placebo pill 2 times daily. All subjects received medications for 6 months. The chi-squared or Fisher exact tests were used to assess drug efficacy with respect to objective findings and symptoms.

RESULTS: A greater percentage of individuals in the clofazimine group had no further aphthous episodes (17%-44% compared with
CONCLUSION: Clofazimine should be considered for the treatment of recurrent aphthous stomatitis.

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