JOURNAL ARTICLE
REVIEW

Toll-like receptors and innate immunity

Himanshu Kumar, Taro Kawai, Shizuo Akira
Biochemical and Biophysical Research Communications 2009 October 30, 388 (4): 621-5
19686699
Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in various immune and non-immune cells of the mammalian host. TLRs play a crucial role in defending against pathogenic microbial infection through the induction of inflammatory cytokines and type I interferons. Furthermore, TLRs also play roles in shaping pathogen-specific humoral and cellular adaptive immune responses. In this review, we describe the recent advances in pathogen recognition by TLRs and TLR signaling.

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