JOURNAL ARTICLE
REVIEW

Emerging clinical concerns in the ageing haemophilia patient

B A Konkle, C Kessler, L Aledort, J Andersen, P Fogarty, P Kouides, D Quon, M Ragni, A Zakarija, B Ewenstein
Haemophilia: the Official Journal of the World Federation of Hemophilia 2009, 15 (6): 1197-209
19686466
The availability of safe replacement clotting factor concentrates together with effective antiviral drugs to treat human immunodeficiency and hepatitis C viruses and the provision of care at designated haemophilia treatment centres have resulted in a new phenomenon in haemophilia management - the ageing patient. Today, increasing numbers of persons with haemophilia (PWH) are middle-aged and older, and they face the same age-related health issues as the general population. The impact of these risks on PWH is unclear, however, and there is a paucity of information about how to manage comorbidities in this patient population. This review focuses on five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease. Available research is summarized and potential management approaches are suggested.

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