A combined measles, mumps, rubella and varicella vaccine (Priorix-Tetra): immunogenicity and safety profile

Hanna Czajka, Volker Schuster, Fred Zepp, Susanna Esposito, Martine Douha, Paul Willems
Vaccine 2009 November 5, 27 (47): 6504-11
Priorix-Tetra (GlaxoSmithKline Biologicals) is a combined measles, mumps, rubella and varicella (MMRV) vaccine. Eight studies involving more than 3000 children were reviewed. Compared with co-administration of MMR (Priorix) and varicella (Varilrix) vaccines, the MMRV vaccine showed: similar immunogenicity, with immunity shown up to 3 years post-vaccination; a higher rate of fever after the first dose; a slight increase in mild local reactions after the second dose. This MMRV vaccine can be used either as a two-dose vaccine or as a second dose in children primed with separate MMR and/or varicella vaccines, offering a convenient way to introduce varicella vaccination into routine vaccination programmes.

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