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JOURNAL ARTICLE

REVIEW

Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

Margit Hørup Larsen, Thomas Vauvert F Hviid

Human Immunology 2009, 70 (12): 1026-34

Human leukocyte antigen-G (HLA-G) is a nonclassical class Ib molecule belonging to the major histocompatibility complex. HLA-G appears to play a role in the suppression of immune responses and contribute to long-term immune escape or tolerance. The focus of this review is polymorphism in the HLA-G gene and protein and its possible importance in expression, function, and disease associations.

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